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. Author manuscript; available in PMC: 2013 Aug 15.

Published in final edited form as: Circ Res. 2013 May 21;113(3):288–300. doi: 10.1161/CIRCRESAHA.113.300929

Transplantation of ADSCs with PHD2 silencing reduces infarct size and improves cardiac function in MI mice. A: Representative images of TTC-stained heart sections obtained from Sham, MI+PBS, MI+GFP-ADSCs, and MI+shPHD2-GFP-ADSCs groups at 4 weeks after transplantation. B: LV infarct sizes expressed as the ratio of the length of the infarct band to the total length of LV (N=14). C: Representative M-mode images of hearts with sham surgery or MI at 4 weeks after PBS, GFP-ADSCs and shPHD2-GFP-ADSCs injection. Scale bar: X axis: 0.1 second; Y axis: 0.2 cm. D: Heart rates were controlled to be similar in different groups. E–G: LV fraction shortening (E), LV ejection fraction (F) and diastolic left ventricle internal diameter (LVIDd, G) at 4 weeks after ADSCs transplantation. N=11. * p<0.05 vs. Sham; # p<0.05 vs. MI+PBS; & p<0.05 vs. MI+GFP-ADSCs.

Transplantation of ADSCs with PHD2 silencing reduces infarct size and improves cardiac function in MI mice. A: Representative images of TTC-stained heart sections obtained from Sham, MI+PBS, MI+GFP-ADSCs, and MI+shPHD2-GFP-ADSCs groups at 4 weeks after transplantation. B: LV infarct sizes expressed as the ratio of the length of the infarct band to the total length of LV (N=14). C: Representative M-mode images of hearts with sham surgery or MI at 4 weeks after PBS, GFP-ADSCs and shPHD2-GFP-ADSCs injection. Scale bar: X axis: 0.1 second; Y axis: 0.2 cm. D: Heart rates were controlled to be similar in different groups. E–G: LV fraction shortening (E), LV ejection fraction (F) and diastolic left ventricle internal diameter (LVIDd, G) at 4 weeks after ADSCs transplantation. N=11. * p<0.05 vs. Sham; # p<0.05 vs. MI+PBS; & p<0.05 vs. MI+GFP-ADSCs.