Table 1.
Summary of CS/PC and iPSC therapy in rodent models of acute myocardial infarction
| Cell type | Surface marker(s) | Animal species | Number of cells injected | Route of delivery | Timing of cell delivery | LVEF | Infarct size | Follow-up duration | Reference | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
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| Control | Stem cell | Control | Stem cell | ||||||||
| CS/PCs | |||||||||||
| Cardiospheres | c-kit+, sca-1+ and KDR+ | Mouse | – | IM | Immediately after MI | 18% | 37% | – | – | 3 weeks | [41] |
| c-kit+ | c-kit+ | Rat | 1×106 | IM | 4 h after MI | 40% | 48% | – | – | 5 weeks | [42] |
| Sca-1+ | Sca-1+ and CD31− | Mouse | 1×106 | IM | Immediately after MI | 31% | 38% | – | – | 3 weeks | [43] |
| SSEA-1+ | SSEA-1+ | Rat | 1×106 | IM | 2 weeks after MI | 28% | 57% | – | – | 5 weeks | [44] |
| CDC (human) | c-kit+, CD90+ and CD34+ | Mouse | 1×105 | IM | Immediately after MI | 26.0 ± 1.8% | 42.8 ± 3.3% | – | – | 3 weeks | [45] |
| CDC | c-kit+ and lin− | Mouse | 1×106 | IV | 1 h after MI | 35% | 43% | 50% | 36% | 4 weeks | [46] |
| Sca-1+ | Sca-1+ | Rat | 1×106 | IM | Immediately after MI | 28.3 ± 4.7% | 43.3 ± 2.8% | 51.9 ± 5.6% | 38.8 ± 1.2% | – | [47] |
| CDC | c-kit+ and nkx2.5+ | Mouse | 1×105 | IM | Immediately after MI | 28% | 43% | – | – | 3 weeks | [48] |
| CDC | c-kit+ | Rat | – | Cell sheet | – | 30 ± 3% | 58 ± 15% | – | – | 3 weeks | [49] |
| CDC | c-kit+ | Mouse | – | IM | – | 40.2 ± 4.2% | 51.5 ± 7.4% | – | – | – | [50] |
| CDC | c-kit+ | Neonatal rat | – | IM | Immediately after MI | 47 ± 2% | 56 ± 3% | 16 ± 2% | 10 ± 1% | 16 weeks | [51] |
| EPDC | WT1+ | Mouse | – | IM | Immediately after MI | 21% | 28% | 35% | 24% | 9 weeks | [52] |
| iPSC/iPSC derivatives | |||||||||||
| iPSC | Mouse | 2×105 | IM | Immediately after MI | 37 ± 4% | 50 ± 5% | 4 weeks | [62] | |||
| iPSC-derived CPC | Flk-1+ | Mouse | 5×105 | IM | Immediately after MI | 23 ± 1% | 32 ± 3% | 43 ± 2% | 19 ± 7% | 2 weeks | [60] |
| iPSC-derived cardiomyocyte | Troponin I+ | Rat | 2×106 | IM | Immediately after MI | 45 ± 9% | 62 ± 4% | 16% | 9% | 10 weeks | [65] |
| iPSC-derived CPC | NCX1+ and Cx43+ | Mouse | – | Cell patch | 7 days after MI | 39.3 ± 1.8% | 50.5 ± 1.9% | – | – | 4 weeks | [63] |
| iPSC | Mouse | 5×104 | IM | Immediately after MI | 65.3 ± 2.4% | 75.7 ± 2.1% | – | – | 2 weeks | [64] | |
Cx43, connexin 43; EPDC, epicardium-derived cell; IM, intramyocardial injection; IV, intravenous injections; KDR, kinase insert domain receptor; NCX, Na+/Ca2+ exchanger.