Table IV.

Association between Bcl-2 and DFS in the Danish Cohort of BIG 1 - 98 by univariate analysis.^a

Bcl-2b	n	Periodc	HR	(95% CI)	p
0–9%	37		2.90	(1.83–4.61)	0.0001
10–49%	32		1.23	(0.65–2.34)	0.52
≥ 50%/weak + mod	234	0–5 years	1.41	(1.06–1.90)	0.02
		5–10 years	0.49	(0.23–1.02)	0.06
≥ 50%/strong	888		1.00	(reference)

CI, confidence interval; HR, hazard ratio; mod, moderate.

^a Model stratified by randomization option, allocated treatment and age at randomization.

^b Global test for Bcl-2 (p = 0.0002).

^c Time-dependent variables. If nothing is mentioned the follow-up period is 0 – 10 years postrandomization.