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Sortilin activity does not affect levels of Aβ in plasma or levels of Aβ peptide degrading enzymes in the brain. A, Levels of Aβ40 in plasma of PDAPP+/−; Sort1+/+ and PDAPP+/−; Sort1−/− mice are given. Values are mean ± SEM (n = 4–5 per group). B, Expression levels of CD10 (neprilysin) and insulin degrading enzyme (IDE) in hippocampus (Hip) and cortex (Ctx) mice of the indicated genotypes were determined by Western blotting. Detection of tubulin served as loading control.
