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. Author manuscript; available in PMC: 2014 Apr 29.
Published in final edited form as: Dev Cell. 2013 Apr 29;25(2):196–206. doi: 10.1016/j.devcel.2013.03.017

Figure 7. A Model for Arterial-Venous Differentiation.

Figure 7

At the 10-somite stage endothelial progenitor cells are positioned within the LPM in two bilateral lines, a medial (red) and lateral line (blue). After the 10-somite stage, medial angioblasts migrate intersomitically to the midline directly to the dorsal position where they differentiate as arterial cells. Shortly after the 15-somite stage, the lateral angioblasts migrate to the ventral position at the midline where they differentiate as venous endothelial cells. Hh, expressed in the notochord; VegfA, expressed in the ventral somites function as morphogens and are important for specifying arterial fate in the medial angioblasts.