TABLE 2.

Association between mean learning score^* and other factors with incremental regression models^† (n = 9,853).

PREDICTOR VARIABLE	UNADJUSTED		ADJUSTED FOR DF‡		ADJUSTED FOR DF PLUS BMI§		ADJUSTED FOR DF PLUS BMI PLUS logCRP¶		ADJUSTED FOR DF PLUS BMI PLUS logCRP PLUS RF#		ADJUSTED FOR DF PLUS BMI PLUS logCRP PLUS RF PLUS CES-D**		ADJUSTED FOR DF PLUS BMI PLUS logCRP PLUS RF PLUS CES-D PLUS SES††
	Regression Coefficient (β [95% CI‡‡])	P Value	Regression Coefficient (β [95% CI])	P Value	Regression Coefficient (β [95% CI])	P Value	Regression Coefficient (β [95% CI])	P Value	Regression Coefficient (β [95% CI])	P Value	Regression Coefficient (β [95% CI])	P Value	Regression Coefficient (β [95% CI])	P Value
Teeth Lost (No.)
0 (ref.)
1–5	0.01 (−0.15 to 0.17)	.87	0.06 (−0.08 to 0.21)	.408	0.06 (−0.08 to 0.21)	.395	0.07 (−0.08 to 0.21)	.362	0.09 (−0.05 to 0.24)	.197	0.12 (−0.02 to 0.26)	.101	0.07 (−0.06 to 0.21)	.297
6–16	−0.26 (−0.45 to −0.08)	.005	−0.17 (−0.34 to 0.00)	.048	−0.17 (−0.34 to 0.00)	.044	−0.16 (−0.33 to 0.01)	.060	−0.12 (−0.28 to 0.05)	.163	−0.10 (−0.26 to 0.07)	.249	−0.03 (−0.19 to 0.13)	.689
> 16	−0.52 (−0.65 to −0.38)	< .001	−0.28 (−0.41 to −0.15)	< .001	−0.27 (−0.39 to −0.14)	< .001	−0.25 (−0.38 to −0.12)	.001	−0.18 (−0.31 to −0.05)	.005	−0.16 (−0.29 to −0.04)	.011	−0.01 (−0.13 to 0.12)	.913
Region
Non–Stroke Belt (ref.)
Stroke Belt	NA§§	NA	−0.19 (−0.25 to −0.13)	< .001	−0.18 (−0.24 to −0.12)	< .001	−0.18 (−0.24 to −0.12)	< .001	−0.16 (−0.22 to −0.10)	< .001	−0.16 (−0.21 to −0.10)	< .001	−0.10 (−0.15 to −0.04)	.010
Sex
Male (ref.)
Female	NA	NA	0.75 (0.69 to 0.81)	< .001	0.76 (0.70 to 0.82)	< .001	0.78 (0.72 to 0.84)	< .001	0.75 (0.69 to 0.81)	< .001	0.79 (0.73 to 0.85)	< .001	0.90 (0.84 to 0.96)	< .001
Age (Years)
45–54 (ref.)
55–64	NA	NA	−0.37 (−0.47 to −0.26)	< .001	−0.36 (−0.47 to −0.26)	< .001	−0.35 (−0.46 to −0.25)	< .001	−0.32 (−0.43 to −0.22)	< .001	−0.33 (−0.44 to −0.23)	< .001	−0.27 (−0.37 to −0.17)	< .001
65–74	NA	NA	−1.01 (−1.11 to −0.90)	< .001	−1.01 (−1.12 to −0.91)	< .001	−1.01 (−1.11 to −0.90)	< .001	−0.96 (−1.07 to −0.85)	< .001	−0.99 (−1.09 to −0.88)	< .001	−0.80 (−0.90 to −0.69)	< .001
75–84	NA	NA	−1.73 (−1.85 to −1.61)	< .001	−1.76 (−1.88 to −1.63)	< .001	−1.75 (−1.87 to −1.62)	< .001	−1.71 (−1.83 to −1.58)	< .001	−1.72 (−1.85 to −1.60)	< .001	−1.44 (−1.57 to −1.32)	< .001
85 or older	NA	NA	−2.35 (−2.63 to −2.07)	< .001	−2.39 (−2.67 to −2.11)	< .001	−2.38 (−2.66 to −2.10)	< .001	−2.39 (−2.67 to −2.11)	< .001	−2.38 (−2.66 to −2.10)	< .001	−2.12 (−2.38 to −1.85)	< .001
Income ($)
< 20,000 (ref.)
20,000–34,999	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.30 (0.21 to 0.39)	< .001
35,000–74,999	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.48 (0.39 to 0.57)	< .001
75,000 or higher	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.70 (0.59 to 0.81)	< .001
Education Level
No high school diploma (ref.)
High school diploma or general equivalency degree	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.44 (0.33 to 0.55)	< .001
Some college but no degree	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.67 (0.56 to 0.78)	< .001
College degree or higher	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.91 (0.80 to 1.02)	< .001

^*Mean learning score: Consortium to Establish a Registry for Alzheimer’s Disease word list learning, average of responses across three learning trials (range, 0–10).

^†All P values are based on a likelihood ratio test.

^‡DF: Demographic factors (region, race, sex, age).

^§BMI: Body mass index.

^¶logCRP: Logarithm of C-reactive protein.

^#RF: Risk factors (diabetes, hypertension, hyperlipidemia, smoking).

^**CES-D: Center for Epidemiological Studies-Depression. The scale ranges from zero to 12; a score of four or higher indicates an elevated level of psychological distress.

^††SES: Socioeconomic status (income, education).

^‡‡CI: Confidence interval.

^§§NA: Not applicable.