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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Dev Biol. 2013 Jul 1;1(2):82–91. doi: 10.3390/jdb1020082

Figure 3.

Figure 3

Proepicardial morphological induction. A) Schematic of early mesothelium transitioning to a “ grape-like” cluster of proepicardial cells. FGF signaling and the transcription factor Tbx5 are required for this transition. BMP secreted by atrioventricular junction myocytes direct oriented proepicardial extension. B) Schematic of a looping stage heart. Following proepicardial extension and attachment to the inner curvature of the heart, Alpha4 integrin and Vcam1 are necessary for proper spreading and adherence of epicardial cells to the myocardium. At -atria, AVJ - atrioventricular junction, Vt - ventricle.