Table 1. Efficacy of benznidazole (Bz) and posaconazole (Ps) treatments for 7 days (monotherapy or combination) in murine model of acute Trypanosoma cruzi infection¹.

Experimental groups	Parasitemia clearance (doses)	Number of surviving/total number of animals	Maximum level of parasitemia until 30 days after treatment×103 (mean±SD)
Uninfected	-	6/6	-
Untreated	-	0/6	1,424.6±507.1
Bz 100 mg/Kg/day	1.83±0.75	6/6	95.6±46.8
Ps 20 mg/Kg/day	1.5±0.54	6/6	74.8±38.1
Bz+Ps (100+20 mg/Kg/day)	1.0±0	6/6	13.2±3.9*
Bz 50 mg/Kg/day	1.33±0.51	4/6	174.8±192.8
Ps 10 mg/Kg/day	1.17±0.41	6/6	101.2±1,102.5
Bz+Ps (50+10 mg/Kg/day)	1.4±0.55	5/6	20.1±99.6*
Bz 25 mg/Kg/day	ND	2/6	418.6±518.23
Ps 5 mg/Kg/day	1.17±0.41	4/6	240.2±338.2
Bz+Ps (25+5 mg/Kg/Day)	1.16±0.41	6/6	36.6±28.4*

¹Swiss female (n = 6) weight 20 to 24 g were inoculated with 5×10³ trypomastigotes (Ystrain).

Treatment was started at 4^th day after inoculation followed by 7 daily doses and the drugs were administered orally.

^*Significant difference in relation to benznidazole monotherapy treatment at same dose.

ND – Not detected.