Table 3. Assessment of cure by benznidazole (Bz) and posaconazole (Ps), administered in monotherapy or sequential combinations, in a murine model of Trypanosoma cruzi infection¹.

Experimental groups	Number of surviving/total number of animals	Number of negative FBE2/number of mice	Number of negative blood PCR3 sample/number of mice	Total of negative assays/number of mice
Uninfected	10/10	10/10	10/10	10/10
Untreated	0/10	0/10	ND4	0/10
Bz 100 mpk4/10 days	7/7	0/7	ND5	0/7
Bz 100 mpk/20 days	10/10	8/10	7/10	7/10
Ps 20 mpk/10 days	6/7	0/7	ND6	0/7
Ps 20 mpk/20 days	10/10	10/10	8/10	8/10
Bz 100 mpk followed by Ps 20 mpk	10/10	10/10	8/10	8/10
Ps 20 mpk followed by Bz 100 mpk	10/10	3/10	3/10	3/10

¹Swiss female (n = 10) weight 20 to 24 g were inoculated with 5×10³ trypomastigotes (Y strain).

Treatment was initiated at 4^th day after inoculation followed by 10 or 20 daily doses and it was being orally administered.

²FBE – fresh blood examination performed before and after cyclophosphamide immunossupression.

³PCR assay was performed in the 1^st and 6^th month after treatment.

⁴mpk – milligrams/kilogram/day.

⁵All mice died before 30 days of infection.

⁶All mice had positive results in fresh blood examination.