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. 2013 Aug 15;9(8):e1003671. doi: 10.1371/journal.pgen.1003671

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© 2013 He et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A fraction of the genes are associated with the phenotype under investigation and follow model , and the remainder follow model . The prior distribution of gene-specific parameters, relative risk () and allele frequency (), can vary under the competing models, or . Priors are specified by the hyperparameters, and , respectively, which are estimated from the data. Counts of events for the i-th gene follow a Poisson distribution, parameterized by and under , and under .

Inline graphic — A fraction of the genes are associated with the phenotype under investigation and follow model , and the remainder follow model . The prior distribution of gene-specific parameters, relative risk () and allele frequency (), can vary under the competing models, or . Priors are specified by the hyperparameters, and , respectively, which are estimated from the data. Counts of events for the i-th gene follow a Poisson distribution, parameterized by and under , and under .