Figure 7. Znf3 regulates pheromone expression activating the pheromone signaling cascade and promotes transposon silencing.

Mat2 is the transcription factor target of the pheromone signaling cascade that binds to the pheromone response element (PRE) in the promoter of the pheromone gene. Znf3 is required for induced levels of the pheromone and transposon silencing. Znf3 may bind additional cis-regulatory element to inhibit transposon mobilization during sexual development or function by binding to RNA targets.