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. 2013 Aug 15;9(8):e1003699. doi: 10.1371/journal.pgen.1003699

Figure 7. A model for TFIIIC-dependent regulation of activity-regulated transcription.

Figure 7

(A and B) In resting conditions (left), TFIIIC is bound to SINEs located in the proximity of poised, activity dependent genes. TFIIIC keeps gene loci away from transcription factories, thereby inhibiting transcription. (A) In response to depolarization, p300 is recruited to SINEs and co-regulated genes come in close proximity within shared TFs, where they become transcriptionally activated. (B) Alternatively, upon depolarization TFIIIC undergoes a functional switch, p300 is recruited to SINEs and genes relocate to TFs where they become transcriptionally activated.