Table 4. LPC16∶0 and LPC20∶4 negatively correlate with CVD risk factors whereas SM38∶2 positively correlates with CVD risk factors.
Lipid specie | LPC16∶0 | LPC20∶4 | SM38∶2 | ||||||
Correlation | P | q-value | Correlation | P | q-value | Correlation | P | q-value | |
Imtcca0 | −0.13 | 0.010 | 0.007 | −0.03 | 0.591 | 0.218 | 0.09 | 0.112 | 0.062 |
HbA1c | −0.12 | 0.012 | 0.009 | −0.09 | 0.074 | 0.043 | −0.05 | 0.385 | 0.163 |
BMI | −0.14 | 0.004 | 0.003 | −0.19 | 2.0E-04 | 2.2E-04 | 0.04 | 0.438 | 0.180 |
SBP | −0.06 | 0.244 | 0.114 | −0.11 | 0.039 | 0.025 | −0.02 | 0.710 | 0.247 |
LDL | 0.07 | 0.154 | 0.081 | −0.05 | 0.356 | 0.153 | 0.36 | 7.4E-11 | 2.6E-09 |
HDL | 0.12 | 0.014 | 0.011 | 0.18 | 5.5E-04 | 5.8E-04 | 0.06 | 0.262 | 0.121 |
Partial correlations were performed between LPC16∶0, LPC20∶4, or SM38∶2 after log transformation and current known laboratory predictors for cardiovascular disease, adjusting for age and sex. BMI, body mass index; HbA1c, haemoglobin A1c; HDL, high-density lipoprotein cholesterol; Imtcca0, intima-media thickness of the common carotid artery at baseline; LDL, low-density lipoprotein cholesterol; LPC, lysophosphatidylcholine; SBP, systolic blood pressure; SM, sphingomyelin.