Table 3. Calcium and phosphate homeostasis among groups.

		Groups (number of patients)
		LAA (48)	MAA (53)	HAA (53)	ANOVA	ANCOVA
Phosphatemia (mmol/L)	mean ± SD	1.67 ± 0.32	1.49 ± 0.34*	1.38± 0.33*§	<0.001	<0.001
Calcemia (mmol/L)	mean ± SD	2.37 ± 0.21	2.41 ± 0.22*	2.41 ± 0.22*	<0.001	<0.001
Calciuria (mmol/kg/d)	mean ± SD	0.06 ± 0.06	0.12 ± 0.15*	0.19 ± 0.22*§	<0.001	<0.001
Calcium Balance (mg/kg/d)	mean ± SD	45.6 ± 10.2	44.7 ± 10.9	42.4 ± 12.9	n.s.
Severe hypophosphatemia	N of cases (%)	0/136 (0.0)	6/130 (4.6)*	21/168 (12.5)*	<0.001
	N of infants (%)	0/48 (0.0)	3/53 (5.7)	10/53 (18.9)*	<0.001
Severe hypercalcemia	N of cases (%)	4/213 (1.9)	12/248 (4.8)*	29/295 (9.8)*	<0.001
	N of infants (%)	3/48 (6.2)	8/53 (15.1)	16/53 (30.2)*	0.05

LAA group: <1.5 g/kg/day of mean AA intake; MAA group: 1.5-2 g/kg/d of mean AA intake; HAA group: >2 g/kg/day of mean AA intake. Severe hypophosphatemia is defined to be < 1 mmol/L , severe hypercalcemia is defined as > 2.8 mmol/L . *p<0.05 versus LAA group . §p<0.05 versus MAA group.