Table 3. Logistic regression analysis for the contribution of CETP 405V to longevity under different genetic models.
| Variable | Stratification | Wald | P | OR (95%CI) | |
|---|---|---|---|---|---|
| Gender | Male / Female | 157.870 | <0.001 | 0.177 (0.136-0.232) | |
| CETP | overall | Additive(VV/VI/II) | 11.293 | 0.004 | NA |
| Dominant(VV +VI/II) | 10.419 | 0.001 | 0.643 (0.492-0.841) | ||
| Recessive (VV/VI+II) | 3.739 | 0.053 | 0.733 (0.535-1.004) | ||
| Number of V allele | 10.425 | 0.001 | 0.746 (0.624-0.891) | ||
| Male | Additive(VV/VI/II) | 16.440 | <0.001 | NA | |
| Female | Additive(VV/VI/II) | 9.103 | 0.011 | NA | |
| Model 1a | overall | Additive(VV/VI/II) | 11.146 | 0.004 | NA |
| Dominant(VV +VI/II) | 8.321 | 0.004 | 0.650 (0.485-0.871)a | ||
| Recessive (VV/VI+II) | 6.439 | 0.011 | 0.640 (0.453-0.903)a | ||
| Number of V allele | 11.133 | 0.001 | 0.718 (0.591-0.872)a | ||
| Model 2b | overall | Additive(VV/VI/II) | 9.560 | 0.008 | NA |
| Dominant(VV +VI/II) | 6.996 | 0.008 | 0.673 (0.501-0.902) | ||
| Recessive (VV/VI+II) | 5.691 | 0.017 | 0.654 (0.462-0.927) | ||
| Number of V allele | 9.558 | 0.002 | 0.734 (0.604-0.893) | ||
| APOE interaction | overall | 405V by ε4 | 10.851 | 0.001 | 0.530 (0.363-0.773) |
Logistic regression analysis: risk (OR) of longevity, NA = not available
Dependent variable: longevity group (1) vs. control group (0); Independent variables: Gender (male: 1, female: 0)
a Logistic model 1: adjusted for gender; b Logistic model 2: adjusted for gender, APOE ε4 number, body mass index and concentration of HDL-c