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. 2013 Aug 15;8(8):e72121. doi: 10.1371/journal.pone.0072121

Figure 4. Inhibition of MMP-9 increases Notch signaling in skeletal muscle of mdx mice.

Figure 4

GA muscles were isolated from 8-week old mdx;Mmp9+/+ and mdx;Mmp9+/− mice and processed for QRT-PCR analysis. Fold change in expression of (A) Notch receptors- Notch1, Notch2 and Notch3; (B) Notch ligands- Jagged1, Jagged2, DLL1 and DLL4; and (C) Notch target genes- Hes1, Hes6, HeyL, and Hey1. N = 3–4 in each group. Error bars represent SD. *p<0.05, values significantly different from littermate mdx;Mmp9+/+ mice.