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. 2013 Aug 15;8(8):e72121. doi: 10.1371/journal.pone.0072121

Figure 5. Inhibition of MMP9 improves canonical Wnt pathway but suppresses non-canonical Wnt signaling.

Figure 5

GA muscles isolated from 8-week old mdx;Mmp9+/+ and mdx;Mmp9+/− mice and processed for QRT-PCR or Western blotting. (A) Relative mRNA levels of Wnt3a, Wnt4, Wnt5a, Wnt7a and Wnt11. (B) Relative mRNA levels Frizzled (Fzd)1, Fzd2, Fzd4 and Fzd6. (C) Relative mRNA levels of Axin2. N = 3 (for Western) and N = 3 (for QRT-PCR) in each group. (D) Representative immunoblots showing Wnt3a and Axin2 and unrelated protein tubulin in GA muscle. Error bars represent SD. *p<0.01, values significantly different from littermate mdx;Mmp9+/+ mice.