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. 2013 Aug 15;8(8):e72612. doi: 10.1371/journal.pone.0072612

Figure 6. Kinetics of combination of GLP-1 and glucose stimulated insulin release from Islet TF model.

Figure 6

Effect of GLP-1 on the kinetics of a subsequent glucose-stimulated insulin release from rat islets cultured in Islet TF model was studied. Islets cultured in Islet TF were stimulated with 1 ng/ml GLP-1 from min 0 to 60 combined with medium glucose concentration increasing from 2.6 mM to 8 mM from min 30 to 60 (black line). The control release of insulin by islets cultured in Islet TF with glucose concentration increasing alone is also shown (grey line). Values are means ± SEM of 3 independent experiments, each performed in duplicate.