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. 2013 Aug 15;8(8):e72474. doi: 10.1371/journal.pone.0072474

Figure 4. Osteogenic gene expression of ASCs in monolayer culture.

Figure 4

Osteogenic gene markers including Runx2 (A), ALP (B), ON (C), Col1a (D) and OCN (E), were elevated in ASCs transduced with noggin shRNA in the presence or absence of BMP-2 as analyzed by quantitative real-time PCR at day 14 (*p<0.05, ** p<0.01 compared to their corresponding controls transduced with control shRNA). Significant up-regulation of all genes was observed after treatment with different doses of BMP-2 (§ p <0.05, §§ p <0.01).