Figure 2. Changes in weighted and un-weighted average UniFrac distances in formerly GF wild-type (WT) and IL-10^−/− mice over time. (A) Average weighted UniFrac distances of the intestinal microbiota significantly decrease in IL-10^−/− mice three and four weeks following colonization with a specific-pathogen free (SPF) microbiota. (B) Average un-weighted UniFrac distances of the intestinal microbiota do not significantly alter in the IL-10^−/− mice following colonization with an SPF microbiota. (C) Average weighted and un-weighted UniFrac distances significantly increase in WT mice between one and two weeks following colonization with an SPF microbiota.