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. 2013 Aug 15;8(8):e72347. doi: 10.1371/journal.pone.0072347

Figure 2. PACAP 6-38 blocks CARTp-induced reduction in body weight.

Figure 2

Effects by fourth i.c.v. drug treatment on body weight changes (mean g ± SE). (A) The animals receiving CARTp had significantly decreased body weight on the day after fourth i.c.v. injections (22 h post injection); however, PACAP 6-38 (P) was able to mitigate the weight loss effects observed in the animals. (B) During the 24 h preceding the next treatment session (i.e., 2 days later), all animals again displayed stable positive weight changes that were similar across groups, regardless of the preceding treatments. Significance from Tukey’s post-tests after repeated measures ANOVA are indicated: *p<0.05; **p<0.01; ***p<0.001. All significant differences shown in the figure are vs. the vehicle control condition.