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. 2013 Aug 15;8(8):e71536. doi: 10.1371/journal.pone.0071536

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© 2013 Kondeti et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Hypothetical mechanism(s) depicting cys-LT-mediated signaling in MCs by PKCs. CysLT₁R activation by LTD₄ or LTE₄ activates PKCα and PKCε. PKCα desensitize CysLT₁R by phosphorylating the receptor and negatively regulating the calcium flux. On the other hand, PKCε activation by CysLT₁R activates c-fos expression, MIP1β production. Cys-LTs also activate Erk and CREB independent of PKCs.