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. 2013 Aug 15;8(8):e71549. doi: 10.1371/journal.pone.0071549

Figure 1. Rhesus monkeys display a naturally occurring cellular immune status against B-LCL.

Figure 1

A) PBMC proliferate ex vivo when cultured with autologous B-LCL (n = 9). The response increased from 835±288 cpm to 16920±3076 cpm (P = 0.0039; Wilcoxon matched pairs test). B) A representative example (animal A4) of the phenotype of proliferating T-cells (percentage cells that have diluted CFSE) present in the natural repertoire proliferating ex vivo against B-LCL. Solid histograms show proliferation in the absence of B-LCL, black lines show proliferation in the presence of B-LCL. C) Mean CFSE dilution in the absence of B-LCL (n = 15; black bars) and in the presence of B-LCL (n = 9). Consistent with the literature on EBV, these are CD3+CD8+ (regular CTL) and CD3−CD56+ (NK). Interestingly, also CD3+CD8+CD56+ T-cells proliferate, which are presumably NK-CTL, a subtype that is of interest for the EAE model [18].