Table 2. IgG responses.
Group | Animal | MOG34–56 | CMVmcp981–1003 | cMOG34–56 | rhMOG |
A (MOG34–56) | A1 | − | − | − | − |
A2 | ++ | − | − | ++ | |
A3 | − | − | − | − | |
A4 | − | − | − | − | |
A5 | +++ | − | + | +++ | |
B (CMVmcp981–1003) | B1 | ++ | − | - | + |
B2 | + | − | − | + | |
B3 | − | +* | − | +* | |
B4 | ++ | − | + | ++ | |
B5 | ++ | − | + | ++ | |
C (cMOG34–56) | C1 | − | − | − | +* |
C2 | +* | +* | + * | + * | |
C3 | − | − | − | − | |
C4 | − | − | − | − | |
C5 | − | − | − | − |
Positive responses developed before the booster immunization on day 98.
A positive antibody response was defined as the light absorbance at 405 nm being >1.5 times than the absorbance of the day-0 sample on at least two time points.