Table 3. CNS histopathology.
Group | Perivascular CD3+ cell clusters | CD3+ cluster in meninges | CD3+CD20+ cluster in meninges | Perivascular edema with CD68+ cells |
Normal brain | 0/7 | 0/7 | 0/7 | 0/7 |
A (MOG34–56) | 2/5 | 1/5 | 1/5 | 1/5 |
B (CMVmcp981–1003) | 3/5 | 1/5 | 0/5 | 1/5 |
C (cMOG34–56) | 5/5 | 4/5 | 2/5 | 2/5 |
Shown is the occurrence (number of animals/total number of animals) of perivascular CD3+ cell, CD3+ and CD3+CD20+ (in brackets) clusters in the meninges and perivascular edema with CD68+ cells. Positive animals were identified as having several clusters containing >4 positive cells in more than one location.