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Possible role of β in Okazaki fragment maturation. During lagging strand synthesis, β clamps are left behind on lagging strand fragments. The remaining β clamps may serve to target Pol I to the lagging strand for removal of the RNA used to initiate each fragment. The β subunit interaction with ligase may serve a similar purpose in targeting, or otherwise aiding, DNA ligase in sealing lagging strand fragments after Pol I action.
