Table 3.

Replication Results of Smoking-related DNAm from Caucasian Populations

Platform	DNAm site	Gene/Locus	t-stat	p-value	Adjusted p-value#
HumanMethylation27	cg03636183**	F2RL3	−15.0	6.21×10−42	6.90×10−42
(Breitling et al. 2011)	cg19859270	GPR15	−6.84	2.45×10−11	6.04×10−16
(Wan et al. 2012)	cg02564523	ORAI2	−1.74	0.082	0.078
	cg09155905	FNDC8	−1.01	0.313	0.207
	cg09084200	NCAPD3	−4.56	6.39×10−6	1.86×10−5
	cg09837977	LRRN3	−3.04	2.53×10−3	2.40×10−7
	cg01500140	LIM2	5.00	8.10×10−7	6.92×10−8
	cg13247990	MYLK	2.33	2.00×10−2	0.025
	cg01988129	ADHFE1	0.86	0.389	0.103
	cg16254309	CNTNAP2	−2.89	4.07×10−3	2.47×10−3
	cg18881723	SLAMF1	−3.06	2.32×10−3	0.036
	cg12044210	APBA2	NA*	NA*	NA*
	cg21917349	APBA2	3.07	2.25×10−3	7.54×10−3
	cg15691199	CEBPE	−2.87	4.29×10−3	0.031
	cg24262469	TIPARP	−1.29	0.199	0.205
	cg05445326	TM4SF19	3.79	1.70×10−2	3.00×10−3
	cg15258980	ARHGAP25	−4.65	4.36×10−6	1.84×10−4
	cg10161121	FASLG	1.82	6.97×10−2	0.920
HumanMethylation450	cg06644428	2q37.1	−3.87	1.49×10−4	5.75×10−4
(Shenker et al. 2012)	cg05951221	2q37.1	−6.35	1.34×10−9	2.30×10−8
	cg21566642	2q37.1	−7.71	5.32×10−13	4.84×10−11
	cg01940273	2q37.1	−7.46	2.37×10−12	4.02×10−11
	cg23576855	AHRR	−8.34	1.06×10−14	1.36×10−12
	cg05575921	AHRR	−9.77	9.51×10−19	4.84×10−18
	cg21161138	AHRR	−5.84	2.04×10−8	4.47×10−7
	cg06126421	6p21.33	−6.81	1.04×10−10	1.00×10−11

^*The DNAm site was excluded from analysis due to non-unique probe sequence.

^**DNAm site (cg03636183) in F2RL3 has been previously reported using both 27K and 450K platforms.

^#additional adjustment for PLC subtype proportions.