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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Oral Oncol. 2013 Jun 28;49(9):845–853. doi: 10.1016/j.oraloncology.2013.05.013

Figure 2.

Figure 2

Schematic representation of two prevailing hypotheses for tumorigenesis, i.e. the cancer stem cell hypothesis and the tumor-initiating cell hypothesis. Adapted by authors from Reya et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414(6859):105–111.