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. 2013 Jul 24;33(30):12255–12274. doi: 10.1523/JNEUROSCI.5108-12.2013

Figure 1.

Figure 1.

a, The investigation consisted of three parts. First, we used DW-MRI tractography to parcellate human DFC. This approach has previously been shown to identify many of the key cytoarchitectonic regions when applied to other brain areas. Second, we examined resting-state BOLD coupling patterns between the dorsal frontal clusters we had found in the first step and regions in other parts of the human brain. Finally, we examined resting-state BOLD coupling patterns between dorsal frontal regions in the macaque. We examined BOLD coupling patterns because, in comparison with DW-MRI tractography, they are less affected by the distance between brain regions. They can therefore be used to illustrate in which cortical networks the areas participate in both humans and macaques. The networks associated with different frontal areas can then be compared and the resting-state functional coupling patterns in the macaque can be compared with the known anatomical connections in the same species. b, The dorsal frontal region investigated extended from the inferior frontal sulcus on the lateral surface to the cingulate sulcus on the medial surface. Rostrally, it included the frontal pole, and caudally it extended to the superior precentral sulcus or to a similar position on the medial surface. The region investigated therefore included all the tissue commonly called dorsolateral PFC, dorsomedial PFC, pre-SMA, SMA, FEF, and dorsal parts of the frontal pole and parts of PMd. The degree of overlap in the area investigated in nine subjects after registration to standard MNI space is indicated by the color (scale bar shown at center). c, Summary of the 10 right DFC regions revealed by the tractography-based parcellation in the nine human subjects studied. The results are presented in more detail in Figures 5, 6, 7, 8, 10, 11, 12, 14, and 15. We refer to cluster 1 as SMA, cluster 2 as preSMA, cluster 3 as area 9, cluster 4 as area 10, cluster 5 as area 9/46d, cluster 6 as area 9/46v, cluster 7 as area 46, cluster 8 as area 8A, cluster 9 as the rostral PMd, and cluster 10 as area 8B.