Fig. 2.

Comparison of the EMMPRIN mRNA expressions among a conventional astrocytoma cell lines (n = 36), b glioblastoma stem-like cells (n = 27), and c astrocytoma primary culture cells (n = 12) from GDS3885 dataset of GEO profile. Glioma cell lines recapitulated the transcriptional value of EMMPRIN in the above three types of glioma cells. d–f Alterations of EMMPRIN, EST1, and p16 mRNA expressions after serial passages. The mRNA expression in serial passages of glioma-stem like cells showed decreased EMMPRIN and EST1, but increased p16 when comparing early to late passages