Table 3.
Group analyses showing cortical changes both of atrophy and microstructure in patients compared with controls at 12 months
| Z score | p value (FWE-corrected) | Cluster extent (voxels) | x (mm) | y (mm) | z (mm) | |||
|---|---|---|---|---|---|---|---|---|
| M1 or S1 region of interest | ||||||||
| Left | ||||||||
| R1 | ||||||||
| M1 | 4·04 | <0·001 | 169 | −1·0 | −24·0 | 56·0 | ||
| M1 | 3·48 | 0·0469 | 30 | −44·0 | −13·0 | 43·0 | ||
| S1 | 4·12 | 0·0009 | 45 | −52·0 | −16·0 | 46·0 | ||
| S1 | 3·76 | 0·001 | 54 | −58·0 | −19·0 | 41·0 | ||
| S1 | 4·09 | 0·0061 | 34 | −32·0 | −35·0 | 52·0 | ||
| S1 | 3·84 | 0·0201 | 29 | −33·0 | −43·0 | 68·0 | ||
| MT | ||||||||
| M1 | 5·03 | <0·001 | 89 | −1·0 | −24·0 | 54·0 | ||
| M1 | 4·15 | <0·001 | 168 | −37·0 | −17·0 | 43·0 | ||
| M1 | 3·92 | <0·001 | 96 | −30·0 | −25·0 | 54·0 | ||
| S1 | 3·92 | <0·001 | 310 | −45·0 | −17·0 | 35·0 | ||
| S1 | 3·99 | 0·0027 | 38 | −32·0 | −35·0 | 52·0 | ||
| S1 | 4·40 | <0·001 | 66 | −29·0 | −41·0 | 56·0 | ||
| VBM | ||||||||
| M1 | 4·11 | 0·0398 | 235 | −7·5 | −37·5 | 73·5 | ||
| Right | ||||||||
| R1 | ||||||||
| M1 | 3·86 | <0·001 | 137 | 50·0 | −6·0 | 38·0 | ||
| S1 | 4·19 | <0·001 | 105 | 35·0 | −41·0 | 56·0 | ||
| S1 | 4·48 | <0·001 | 139 | 55·0 | −14·0 | 40·0 | ||
| S1 | 3·95 | 0·0007 | 34 | 8·0 | −32·0 | 78·0 | ||
| S1 | 4·08 | 0·0026 | 46 | 46·0 | −36·0 | 54·0 | ||
| S1 | 4·02 | 0·0042 | 38 | 9·0 | −46·0 | 76·0 | ||
| S1 | 4·27 | 0·0124 | 44 | 59·0 | −19·0 | 47·0 | ||
| MT | ||||||||
| M1 | 4·91 | <0·001 | 164 | 3·0 | −29·0 | 61·0 | ||
| M1 | 4·85 | <0·001 | 85 | 27·0 | −28·0 | 59·0 | ||
| M1 | 4·84 | <0·001 | 76 | 34·0 | −35·0 | 54·0 | ||
| M1 | 4·73 | <0·001 | 104 | 24·0 | −28·0 | 58·0 | ||
| S1 | 5·40 | <0·001 | 819 | 48·0 | −11·0 | 34·0 | ||
| S1 | 4·73 | <0·001 | 71 | 59·0 | −6·0 | 29·0 | ||
| S1 | 4·17 | 0·0304 | 34 | 59·0 | −19·0 | 47·0 | ||
| CST region of interest | ||||||||
| Left | ||||||||
| R1 | 3·88 | <0·001 | 4033 | −32·0 | −34·0 | 28·0 | ||
| VBM | 4·49 | 0·0248 | 203 | −6·0 | −33 | −58·5 | ||
| Right | ||||||||
| R1 (cluster 1) | 3·58 | <0·001 | 68 | 11·0 | −43·0 | −33·0 | ||
| R1 (cluster 2) | 3·41 | 0·0035 | 107 | 6·0 | −43·0 | −52·0 | ||
| MT | 4·10 | 0·0083 | 322 | 20·0 | −40·0 | 51·0 | ||
Only clusters with significant differences between patients and controls are shown for the VBM and MPM data (ie, MT and R1). FWE=family wise error. VBM=voxel-based morphometry. CST=corticospinal tract. MPM=multiparametric mapping. MT=magnetisation transfer. R1=longitudinal relaxation rate. M1=primary motor cortex. S1=primary sensory cortex.