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. 2013 Apr 25;14(7):810–822. doi: 10.1111/tra.12071

Figure 6. Increased surface expression of GluK2 requires PKC activation.

Figure 6

A) Representative biotinylation and immunoblots showing surface expression of GluK2 after kainate treatment. Application of chelerythrine (CLT) after kainate stimulation did prevent the kainate-induced increase of KARs in the plasma membrane (lanes 3 and 4), but preincubation with chelerythrine (lanes 7 and 8) or primaquine (PMQ, lanes 5 and 6) blocked the kainate-induced increase of KARs in the surface. Lower panel shows the KAR immunoreactivity in the lysates (input). B) Quantification of data shown, mean ± SEM, n = 4.