Fig. 2.

Neuroprotective, plasticity-enhancing and functional neurological improving effects of ibuprofen-mediated RhoA-inhibition after experimental spinal cord injury (SCI). Survey of statistically significant observations (depicted from: Xing et al. 2011; Sharma and Winkler 2002; Wang et al. 2009; Fu et al. 2007). a Differences in cell survival, tissue protection and sprouting responses in ibuprofen-treated animals relative to vehicle controls were calculated from the published original data. Neuroprotective effects were detectable within the first week after SCI. Enhanced myelination and spouting of distinct fiber tracts were observed several weeks after SCI. Because the effects on apoptosis and myelination (Xing et al. 2011) were principally similar for areas caudal and rostral to the injury site, average values from caudal and rostral areas are presented here (BSCB blood-spinal-cord-barrier, CST corticospinal tract, MBP myelin basic protein, LFB Luxol fast blue). b Results of behavioral testing in the ibuprofen and vehicle groups. The BBB scale (Basso-Beattie-Bresnahan scale, Basso et al. 1995) differences are expressed as absolute scale categories and the respective categories are explained in the graph