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. 2013 Aug 16;7:410. doi: 10.3389/fnhum.2013.00410

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Copyright © 2013 de Greck, Bölter, Lehmann, Ulrich, Stockum, Enzi, Hoffmann, Tempelmann, Beutel, Frommer and Northoff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain activity modulated by multimodal psychotherapy. Using a voxel-wise whole brain analysis, we found three regions for the contrast “anger”-“control” and one for the contrast “joy”-“control”, which had a significant increase (bilateral parahippocampal gyrus, left inferior frontal cortex) or decrease (left putamen) of hemodynamic modulation after psychotherapy. The p-threshold was set to p_{[uncorrected]} ≤ 0.001; only clusters with a cluster size of more than 10 voxels were taken into account. (Abbreviations: h, p1, and p2 refer to the mean fMRI signal difference of the according contrast, where h indicates data of healthy subjects, p1 indicates data of pre-treatment somatoform patients, and p2 indicates data of post-treatment somatoform patients; error bars indicate the 95%-confidence-interval).