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. Author manuscript; available in PMC: 2013 Aug 16.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Jan 30;19(6):1749–1752. doi: 10.1016/j.bmcl.2009.01.083

Scheme 1.

Scheme 1

Synthesis of the target 5-benzylidene rhodanine-3-acetic acid derivatives 2a–j. Reagents and conditions: NH4OAc, DMF, 80 °C, 3 h (2a) or EtOH, piperidine, 80 °C, 3–6 h (2b–j). For substituents R1–R3 see Table 1.