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. 2011 Jan 18;19(2):95–105. doi: 10.1016/j.jsps.2011.01.002

Table 6.

Disintegration (DT) and dissolution characteristics of chloroquine phosphate tablets at relative density = 0.90 (mean ± SD, n = 4).

Starch Starch concentration (%) DT (min) t50 (min) t80 (min) t1 (min) k1 k2
0.00 1.80 ± 0.09 14.00 ± 0.50 25.00 ± 0.50 15.00 ± 0.50 0.05 ± 0.00 0.08 ± 0.00



Bitter 2.50 6.75 ± 0.06 16.50 ± 0.53 30.00 ± 0.25 30.00 ± 0.18 0.05 ± 0.00 0.09 ± 0.00
5.00 12.10 ± 0.11 22.50 ± 0.51 40.00 ± 0.50 30.50 ± 0.50 0.04 ± 0.00 0.08 ± 0.00
7.50 14.10 ± 0.06 25.50 ± 0.50 42.50 ± 0.50 40.00 ± 0.43 0.04 ± 0.00 0.07 ± 0.00
10.00 22.50 ± 0.08 40.00 ± 0.23 59.00 ± 0.20 41.00 ± 0.66 0.03 ± 0.00 0.06 ± 0.00



Chinese 2.50 9.25 ± 0.05 20.00 ± 0.25 36.25 ± 0.25 30.00 ± 1.00 0.04 ± 0.00 0.10 ± 0.00
5.00 16.50 ± 0.09 32.50 ± 0.50 49.00 ± 0.25 38.75 ± 0.25 0.03 ± 0.00 0.09 ± 0.00
7.50 24.60 ± 0.05 39.00 ± 0.15 57.50 ± 0.50 40.50 ± 0.66 0.02 ± 0.00 0.06 ± 0.00
10.00 26.25 ± 0.05 46.50 ± 0.50 83.50 ± 0.25 50.00 ± 1.00 0.02 ± 0.00 0.04 ± 0.01



Water 2.50 4.70 ± 0.07 15.50 ± 0.15 28.75 ± 0.25 30.00 ± 1.32 0.06 ± 0.00 0.12 ± 0.00
5.00 5.10 ± 0.19 16.25 ± 0.27 30.50 ± 0.50 30.40 ± 0.22 0.05 ± 0.00 0.10 ± 0.00
7.50 5.30 ± 0.02 19.00 ± 0.18 36.00 ± 0.25 40.00 ± 0.60 0.05 ± 0.00 0.17 ± 0.00
10.00 6.90 ± 0.08 20.00 ± 0.23 37.00 ± 0.25 40.10 ± 0.89 0.04 ± 0.00 0.15 ± 0.00



White 2.50 4.60 ± 0.07 15.50 ± 0.50 28.00 ± 0.50 30.00 ± 0.10 0.05 ± 0.00 0.10 ± 0.00
5.00 5.20 ± 0.25 18.00 ± 0.20 32.50 ± 0.50 30.20 ± 0.72 0.05 ± 0.00 0.09 ± 0.01
7.50 5.90 ± 0.05 22.50 ± 0.35 41.00 ± 0.66 40.00 ± 0.50 0.04 ± 0.00 0.10 ± 0.00
10.00 7.50 ± 0.04 28.00 ± 0.25 47.50 ± 0.40 40.00 ± 1.00 0.03 ± 0.00 0.08 ± 0.01



Corn 2.50 6.60 ± 0.07 17.00 ± 0.25 31.00 ± 0.50 40.00 ± 1.50 0.05 ± 0.00 0.16 ± 0.00
5.00 6.80 ± 0.26 18.00 ± 0.25 33.00 ± 0.39 40.20 ± 0.40 0.04 ± 0.00 0.15 ± 0.00
7.50 7.25 ± 0.04 21.00 ± 0.50 36.50 ± 0.50 40.30 ± 0.27 0.04 ± 0.00 0.11 ± 0.00
10.00 7.30 ± 0.05 20.50 ± 0.50 37.00 ± 0.15 40.00 ± 0.87 0.04 ± 0.00 0.12 ± 0.00