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Comparison of effects of rifampin, ketoconazole, and erythromycin on oral cyclosporine pharmacokinetics.
| Substrate | Fa (%) | Fhep (%) | Fabs × Fg (%) |
|---|---|---|---|
| Cyclosporine | |||
| Alone | 27 (11) | 77 (4) | 33 (13) |
| +Rifampin | 10 (3) | 68 (8) | 14 (5) |
| Cyclosporine | |||
| Alone | 22 (5) | 75 (7) | 30 (8) |
| +Ketoconazole | 56 (12) | 86 (4) | 65 (11) |
| Cyclosporine | |||
| Alone | 36 (9) | 73 (10) | 49d |
| +Erythromycin | 62 (17) | 80 (4) | 78d |
