Table 1.

Stimulation of HR by overexpression of RAD51 and RAD52 cDNAs

Gene	Promoter	Cell line	Levels*	Substrate	Stimulation‖	Ref.
HsRAD52	CMV	Monkey (FSH2)	ND	LacZ†	3–5	45
CgRAD51	SV40	Hamster (SPD8)	1.6–1.8	HPRT‡	2–3	58
CgRAD51	SV40	Hamster (AA8)	2–3	LacZ or neo†	15–35	59
HsRAD51	CMV	Monkey (FSH2)	ND	LacZ†	3–4	60
MmRAD51	CMV	Hamster (DRA-10)	∼2	neo§	2–5	61
HsRAD51	CMV	Human (HT1080)	4	HPRT¶	2–4	62

 Hs, human; Cg, Chinese hamster; Mm, mouse; CMV, cytomegalovirus promoter; SV40, simian virus 40 early promoter; ND, not determined. 

^*Numbers indicate fold expression above endogenous gene. 

^† Intrachromosomal HR between integrated repeats. 

^‡ Intrachromosomal HR between duplicated segments of endogenous HPRT. 

^§ Break-induced and spontaneous intrachromosomal HR between integrated repeats. 

^¶ Gene targeting at HPRT. 

^‖ Numbers indicate fold stimulation relative to normal cells.