Table 3.

Effects of psoralen-modified TFOs on HR in mammalian cells

Cell line	TFO delivery	Adduct	Target	Stimulation¶	Ref.
Human (Jurkat)	Electroporation	Crosslink	supF*	3	208
Monkey (COS)	Electroporation	Crosslink	supF†	25	209
Hamster (AT3-2)	Passive diffusion	Monoadduct	APRT‡	3–5	212
Mouse (LTK-)	Microinjection	Crosslink	TK§	2,500	213

^*Extrachromosomal HR between plasmids. 

^† Extrachromosomal HR in a plasmid duplication. 

^‡ Intrachromosomal HR between duplicated segments of endogenous APRT. 

^§ Intrachromosomal HR between integrated repeats. 

^¶ Numbers indicate fold stimulation relative to untreated cells.