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. Author manuscript; available in PMC: 2013 Aug 16.
Published in final edited form as: Nat Genet. 2008 Apr 13;40(5):650–655. doi: 10.1038/ng.117

Figure 2.

Figure 2

Genome-wide copy number and LOH analysis plot of different cell types within medullary breast cancer sample P5077. DNA of epithelial and stromal cell components were independently analyzed on 500K SNP arrays, and the results were normalized to corresponding normal blood DNA. Purple line is a plot of a 20-SNP moving average of the log2 copy number ratios. Blue and red lines represent allele-specific log2 copy numbers with a value of 0 being equivalent to 1 copy, and a value of –1 equivalent to complete loss of the allele. Note the region of copy number–neutral LOH on chromosome 3p in tumor P5077T (black arrow) as indicated by a near diploid copy number (purple line), whereas the allele-specific copy number shows loss of one allele and a corresponding gain of the other allele. (a) Epithelial cells. (b) Fibroblasts.