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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Oct 2;22(23):7084–7086. doi: 10.1016/j.bmcl.2012.09.093

Table 1.

HDAC inhibition by SAHA, MS-275, and the C6-SAHA analogs 2a–d using HeLa cell lysates

Compounds R IC50, nMa
SAHA 86 ± 4
MS-275 3160 ± 160
2a Methyl 349 ± 28
2b Phenyl 344 ± 44
2c t-Butyl 1940 ± 300
2d 2-Ethylhexyl 456 ± 28
a

Values are the mean of at least three experiments with standard error given.