Table 2.

Physico-chemical characteristics of the SS patches with PEG-400 as plastizer.

Formulation code	Mass uniformity (mg ± SD)a	Thickness (mm ± SD)a	Folding endurance (times)a	Drug content (mg ± SD)a	Drug loading efficiency (%)a	Surface pHa
E1	82.23 ± 4.3	0.55 ± 0.002	250	9.6 ± 0.6	96 ± 0.6	7.1 ± 0.05
E2	86.93 ± 3.1	0.41 ± 0.006	253	9.2 ± 0.4	92 ± 0.4	6.2 ± 0.08
E3	91.42 ± 4.4	0.42 ± 0.002	255	9.1 ± 0.52	91 ± 0.52	6.1 ± 0.12
E4	93.18 ± 2.6	0.43 ± 0.003	260	9.9 ± 0.12	99 ± 0.12	6.9 ± 0.08
E5	101.58 ± 4.5	0.42 ± 0.004	268	9.6 ± 0.87	96 ± 0.87	6.8 ± 0.04
E6	104.91 ± 6.2	0.41 ± 0.003	266	9.0 ± 0.3	90 ± 0.3	6.2 ± 0.17
E7	109.52 ± 7.2	0.48 ± 0.002	>300	9.8 ± 0.9	98 ± 0.9	6.9 ± 0.08
E8	114.28 ± 5.6	0.56 ± 0.006	272	9.0 ± 0.7	90 ± 0.7	6.8 ± 0.01
E9	117.92 ± 4.2	0.57 ± 0.007	275	9.4 ± 0.5	94 ± 0.5	6.1 ± 0.04
E10	69.98 ± 4.2	0.59 ± 0.001	255	9.3 ± 0.8	93 ± 0.8	6.5 ± 0.03
E11	77.58 ± 3.2	0.55 ± 0.002	259	9.8 ± 0.43	98 ± 0.43	6.9 ± 0.07
E12	78.99 ± 6.9	0.48 ± 0.003	>300	9.4 ± 0.92	94 ± 0.92	7.1 ± 0.01
E13	77.32 ± 3.3	0.58 ± 0.008	262	9.1 ± 0.54	91 ± 0.54	6.9 ± 0.06
E14	81.64 ± 2.0	0.52 ± 0.009	268	9.8 ± 0.86	98 ± 0.86	6.8 ± 0.02
E15	85.24 ± 6.9	0.32 ± 0.006	273	9.1 ± 0.9	91 ± 0.9	7.0 ± 0.03
E16	81.66 ± 1.1	0.42 ± 0.007	275	9.6 ± 0.5	96 ± 0.5	7.1 ± 0.04
E17	83.01 ± 1.0	0.39 ± 0.008	274	9.4 ± 0.95	94 ± 0.95	6.8 ± 0.11
E18	84.99 ± 8.1	0.59 ± 0.002	279	9.3 ± 0.32	93 ± 0.32	6.2 ± 0.05

^aAverage of three determinations.