Table 5.

Physical stability characteristics of selected SS patches.

Evaluation parameter	Formulation code	1st month	2nd month	3rd month	5th month	6th month
Drug content (%)⁎	E7	9.7 ± 0.6	9.7 ± 0.8	9.6 ± 0.6	9.6 ± 0.5	9.6 ± 0.6
	E12	9.3 ± 0.9	9.3 ± 0.8	9.2 ± 0.9	9.0 ± 0.2	9.0 ± 0.1
	F7	9.6 ± 0.24	9.6 ± 0.34	9.5 ± 0.3	9.5 ± 0.24	9.5 ± 0.4
	F12	9.1 ± 0.3	9.0 ± 0.62	9.0 ± 0.12	9.0 ± 0.9	9.0 ± 0.4
Residence time⁎	E7	103 ± 2.9	103 ± 2.4	103 ± 3.2	101 ± 3.1	100 ± 2.5
	E12	110 ± 3.2	109 ± 4.1	109 ± 4.6	107 ± 3.5	107 ± 3.9
	F7	100 ± 5.5	109 ± 5.1	109 ± 6.1	109 ± 5.1	107 ± 4.9
	F12	106 ± 5.1	106 ± 5.7	105 ± 4.2	105 ± 4.3	105 ± 5.2
Appearance	E7	No change	No change	No change	No change	No change
	E12	No change	No change	No change	No change	No change
	F7	No change	No change	No change	No change	No change
	F12	No change	No change	No change	No change	No change

^⁎Average of three determinations.