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Downregulation of β2SP in esophageal adenocarcinoma tumor cells increases SOX9 expression and its nuclear localization. A, expression of SOX9 was analyzed in esophageal adenocarcinoma cells with β2SP shRNA knockdown by immunoblotting. B, quantification of SOX9 was determined by densitometry. C, SOX9 and ICN1 expression and localization were analyzed by immunofluorescence.
