Table 3.
Multivariable linear regression of Hounsfield units and continuous cardiometabolic risk factors. Data presented as beta coefficients with 95% confidence intervals per 1 SD decrease in HU
| VAT HU | SAT HU | |||||||
|---|---|---|---|---|---|---|---|---|
| Women β (95% CI) | Women P value | Men β (95% CI) | Men P value | Women β (95% CI) | Women P value | Men β (95% CI) | Men P value | |
| SBP (mm Hg) | ||||||||
| Multivariable | 3.46 (2.66,4.26) | <0.0001 | 2.37(1.72,3.02) | <0.0001 | 2.46 (1.67,3.25) | <0.0001 | 1.15 (0.49,1.81) | 0.0007 |
| + BMI | 1.93 (1.03,2.82) | <0.0001 | 1.43 (0.73,2.14) | <0.0001 | 1.44 (0.64,2.25) | 0.0004 | 0.20 (−0.49,0.89) | 0.57 |
| + Fat volume** | 0.91 (−0.26,2.09) | 0.13 | 0.81 (−0.12,1.74) | 0.09 | 0.90 (0.01,1.78) | <0.05 | −0.03 (−0.82,0.76) | 0.94 |
| DBP (mm Hg) | ||||||||
| Multivariable | 2.27 (1.81,2.73) | <0.0001 | 2.47 (2.05,2.88) | <0.0001 | 1.56 (1.11,2.02) | <0.0001 | 1.48 (1.05,1.91) | <0.0001 |
| + BMI | 1.52 (1.01,2.04) | <0.0001 | 1.93 (1.48,2.38) | <0.0001 | 1.02 (0.56,1.49) | <0.0001 | 0.87 (0.42,1.31) | 0.0002 |
| + Fat volume** | 1.39 (0.71,2.07) | <0.0001 | 1.87 (1.27,2.47) | <0.0001 | 0.67 (0.16,1.18) | <0.01 | 0.74 (0.23,1.25) | 0.005 |
| Fasting plasma glucose (mg/dl) | ||||||||
| Multivariable | 3.64 (2.94,4.35) | <0.0001 | 1.51 (0.50,2.51) | 0.003 | 1.81 (1.09,2.53) | <0.0001 | −0.23 (−1.25,0.79) | 0.66 |
| + BMI | 1.94 (1.15,2.74) | <0.0001 | −0.39 (−1.49,0.71) | 0.49 | 0.59 (−0.14,1.31) | 0.11 | −2.04 (−3.11,−0.97) | 0.0002 |
| + Fat volume** | −0.11 (−1.16,0.94) | 0.84 | −2.06 (−3.52,− 0.59) | 0.006 | 0.03 (−0.77,0.84) | 0.94 | −2.25 (−3.48,−1.01) | 0.0004 |
| Log HOMA-IR*** | ||||||||
| Multivariable | 0.19 (0.17,0.21) | <0.0001 | 0.18 (0.16,0.19) | <0.0001 | 0.09 (0.07,0.11) | <0.0001 | 0.11 (0.09,0.13) | <0.0001 |
| + BMI | 0.11 (0.09,0.14) | <0.0001 | 0.10 (0.08,0.12) | <0.0001 | 0.03 (0.01,0.05) | 0.005 | 0.03 (0.01,0.05) | 0.0053 |
| + Fat volume** | 0.06 (0.03,0.09) | <0.001 | 0.04 (0.01,0.06) | 0.01 | 0.00 (−0.02,0,03) | 0.70 | 0.01 (−0.01,0.03) | 0.43 |
| Log triglycerides (mg/dl) | ||||||||
| Multivariable | 0.20 (0.17,0.22) | <0.0001 | 0.22 (0.19,0.24) | <0.0001 | 0.12 (0.10,0.15) | <0.0001 | 0.11 (0.08,0.14) | <0.0001 |
| + BMI | 0.14 (0.11,0.17) | <0.0001 | 0.19 (0.16,0.21) | <0.0001 | 0.08 (0.06,0.10) | <0.0001 | 0.06 (0.04,0.09) | <0.0001 |
| + Fat volume** | 0.07 (0.04,0.10) | <0.0001 | 0.15 (0.12,0.19) | <0.0001 | 0.06 (0.04,0.09) | <0.0001 | 0.08 (0.05,0.11) | <0.0001 |
| HDL cholesterol (mg/dl) | ||||||||
| Multivariable | −5.15 (−5.95,−4.36) | <0.0001 | −4.36 (−4.90,−3.82) | <0.0001 | −2.56 (−3.37,−1.74) | <0.0001 | −2.01 (−2.58,−1.43) | <0.0001 |
| + BMI | −3.50 (−4.40,−2.59) | <0.0001 | −3.59 (−4.17,−3.01) | <0.0001 | −1.27 (−2.08,−0.45) | 0.002 | −0.98 (−1.57,−0.39) | 0.001 |
| + Fat volume** | −1.91 (−3.09,−0.74) | 0.001 | −3.15 (−3.92,−2.38) | <0.0001 | −0.77 (−1.67,0.14) | 0.1 | −1.22 (−1.90,−0.54) | 0.0005 |
P-value for sex interaction for VAT HU: SBP (p=0.002), DBP (p=0.86), FPG (p=0.0006), HOMA-IR (p=0.23), TG (p=0.59), HDL (p=0.03)
P-value for sex interaction for SAT HU: SBP (p=0.04), DBP (p=0.90), FPG (p=0.004), HOMA-IR (p=0.06), TG (p=0.93), HDL (p=0.47)
VAT-HU regressions adjusted for VAT volume; SAT-HU regressions adjusted for SAT volume.
Among non-diabetic participants with available HOMA-IR data.
Blood pressure indices were also adjusted for hypertension treatment. Glycemic measures were also adjusted for diabetes treatment. Lipid indices were also adjusted for hyperlipidemia treatment.