Table 4.
Multivariable logistic regression of Hounsfield units and dichotomous cardiometabolic risk factors. Data presented as odds ratio with 95% confidence intervals per 1 SD decrease in HU
| VAT HU | SAT HU | |||||||
|---|---|---|---|---|---|---|---|---|
| Women OR (95% CI) | Women P value | Men OR (95% CI) | Men P value | Women OR (95% CI) | Women P value | Men OR (95% CI) | Men P value | |
| Hypertension | ||||||||
| Multivariable | 1.80 (1.58,2.06) | <0.0001 | 1.70 (1.50,1.93) | <0.0001 | 1.21 (1.05,1.40) | 0.0083 | 1.32 (1.16,1.50) | <0.0001 |
| + BMI | 1.44 (1.24,1.68) | <0.0001 | 1.46 (1.28,1.67) | <0.0001 | 1.07 (0.91,1.25) | 0.40 | 1.13 (0.99,1.29) | 0.08 |
| + Fat volume** | 1.15 (0.93,1.42) | 0.19 | 1.20 (1.01,1.42) | 0.04 | 0.96 (0.82,1.13) | 0.63 | 1.04 (0.90,1.20) | 0.63 |
| Impaired Fasting glucose | ||||||||
| Multivariable | 2.10 (1.80,2.44) | <0.0001 | 1.58 (1.41,1.76) | <0.0001 | 1.57 (1.30,1.89) | <0.0001 | 1.36 (1.21,1.53) | <0.0001 |
| + BMI | 1.74 (1.47,2.05) | <0.0001 | 1.45 (1.29,1.64) | <0.0001 | 1.45 (1.19,1.76) | 0.0003 | 1.24 (1.10, 1.39) | 0.0006 |
| + Fat volume** | 1.48 (1.18,1.85) | 0.0006 | 1.34 (1.15,1.56) | 0.0002 | 1.20 (0.99,1.47) | 0.07 | 1.17 (1.02,1.34) | 0.02 |
| Diabetes | ||||||||
| Multivariable | 1.42 (1.12,1.81) | 0.004 | 0.93 (0.77,1.13) | 0.47 | 0.76 (0.62,0.93) | 0.007 | 0.79 (0.66,0.93) | 0.005 |
| + BMI | 0.99 (0.75,1.29) | 0.91 | 0.69 (0.55,0.85) | 0.0007 | 0.65 (0.52,0.82) | 0.0002 | 0.62 (0.51,0.76) | <0.0001 |
| + Fat volume** | 0.43 (0.29,0.65) | <0.0001 | 0.46 (0.35,0.60) | <0.0001 | 0.55 (0.43,0.69) | <0.0001 | 0.54 (0.44,0.66) | <0.0001 |
| Metabolic syndrome | ||||||||
| Multivariable | 3.65 (3.08,4.32) | <0.0001 | 2.90 (2.52,3.34) | <0.0001 | 1.68 (1.42,1.98) | <0.0001 | 1.80 (1.57,2.06) | <0.0001 |
| + BMI | 2.51 (2.09,3.01) | <0.0001 | 2.21 (1.89,2.58) | <0.0001 | 1.47 (1.19,1.82) | 0.0003 | 1.33 (1.14,1.55) | 0.0003 |
| + Fat volume** | 1.53 (1.20,1.95) | 0.0006 | 1.45 (1.20,1.74) | 0.0001 | 1.06 (0.88,1.29) | 0.53 | 1.08 (0.93,1.26) | 0.32 |
| Insulin resistance*** | ||||||||
| Multivariable | 3.36 (2.82,3.99) | <0.0001 | 3.02 (2.54,3.60) | <0.0001 | 1.87 (1.54,2.28) | <0.0001 | 1.94 (1.64,2.31) | <0.0001 |
| + BMI | 2.27 (1.88,2.74) | <0.0001 | 2.26 (1.87,2.74) | <0.0001 | 1.51 (1.19,1.91) | 0.0008 | 1.33 (1.10,1.61) | 0.004 |
| + Fat volume** | 1.46 (1.13,1.89) | 0.003 | 1.56 (1.24,1.95) | 0.0001 | 1.15 (0.92,1.44) | 0.21 | 1.12 (0.92,1.35) | 0.26 |
*
P-value for sex interaction for VAT HU: HTN (p=0.43), IFG (p=0.0009), DM (p=0.01), MetS (p=0.06), IR (p=0.29)
P-value for sex interaction for SAT HU: HTN (p=0.34), IFG (p=0.22), DM (p=0.92), MetS (p=0.11), IR (p=0.44)
**
VAT-HU regressions adjusted for VAT volume; SAT-HU regressions adjusted for SAT volume.
***
Among non-diabetic participants with available HOMA-IR data.
Blood pressure indices were also adjusted for hypertension treatment. Glycemic measures were also adjusted for diabetes treatment.