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. Author manuscript; available in PMC: 2013 Aug 16.
Published in final edited form as: Handb Exp Pharmacol. 2011;206:125–162. doi: 10.1007/978-3-642-21631-2_7

Fig. 5.

Fig. 5

Manipulation of SIRT1 function. Caloric restriction (CR), genetic manipulation, NAD biosynthesis, and sirtuin activating compounds (STACs) increase the dosage/activity of SIRT1, providing beneficial metabolic responses against numerous age-associated physiology and thereby promoting longevity