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. 2013 Jun 28;288(33):23696–23703. doi: 10.1074/jbc.M112.445916

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Eicosanoid biosynthetic pathway and its activation by RTK/GFR → ERK1/2 signaling. Four major branches of the AA metabolic pathway are shown. COX-1/2, cyclooxygenase-1/2-dependent branch. COX-1/2 is also known as prostaglandin-endoperoxide synthase (PTGS) 1/2; LOX, lipoxygenase-dependent branch; CYP450, cytochrome P450-dependent branch; Non-enzymatic, free radical only-dependent branch. Unboxed abbreviations depict proteins and biosynthetic pathways. The boxed symbols identify AA and its metabolites that were measured in the current study by LC/MS/MS.