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. 2013 Jul 5;288(33):23740–23750. doi: 10.1074/jbc.M113.487686

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Piceatannol-enhanced CDDP sensitivity is associated with NOXA up-regulation and p53 activation in p53 wild-type OV2008 cells. A, measurements of mRNA abundance and protein content between 0 and 24 h of CDDP treatment (10 μm) reveal up-regulation of NOXA expression. B, piceatannol treatment (10 μm, 24 h) enhances CDDP-dependent up-regulation of NOXA protein content in a concentration-dependent manner. C, immunoblot analysis of the effect of piceatannol on CDDP-dependent p53 expression and phosphorylation at Ser¹⁵, as well as down-regulation of MDM2 protein content after 24 h. *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus respective dimethyl sulfoxide (DMSO) control.