Table 3. Genotype frequencies of HVEM polymorphisms and their associations with breast cancer risk.
SNP | Minor,(a) | Major,(A) | Cases | Controls | P value for model of inheritance | ||||||
‘AA’ | ‘Aa’ | ‘aa’ | ‘AA’ | ‘Aa’ | ‘aa’ | Additive | Dominant | Recessive | |||
rs2281852 | A | C | 181 | 303 | 81 | 199 | 315 | 90 | 0.8278 | 0.5896 | 0.6595 |
rs1886730 | T | C | 208 | 251 | 105 | 163 | 276 | 161 | 0.0001719 | 0.0003795 | 0.0008484 |
Rs2281852: cases n = 575, missing n = 0; controls n = 604, missing n = 0.
Rs1886730: cases n = 564, missing n = 11; controls n = 600, missing n = 4.
Minor allele ‘a’ and the major ‘A’ are shown in the table. ‘AA’, ‘Aa’, ‘aa’ represent a given variant for each SNP genotyped. Numbers in the columns marked “cases” and “controls” are the numbers of each class of genotype. Significant values (p<0.05) are in bold.